Clinical Research Associate

CRA II (will consider Senior CRA) Late Phase

Home based in the UK

We are seeking a Clinical Research Associate to join ICON Commercialisation & Outcomes (ICO) — our Late Phase business. This is an exciting opportunity to work on post-marketing, real-world, and late phase studies, supporting evidence generation that demonstrates value, safety, and effectiveness in broader patient populations.

As a CRA in our Late Phase team, you will play a critical role in ensuring high-quality delivery across a mix of interventional (IP), observational and medical device studies, in various therapeutic indications, contributing to successful outcomes that shape clinical and commercial strategy.

Key Responsibilities

• Site Monitoring & Oversight
  Conduct on-site and remote monitoring visits across late phase studies, ensuring compliance with protocols, ICH-GCP, regulatory requirements, and applicable device regulations.
• Late Phase Study Delivery
  Support execution of post-authorisation, observational, and interventional studies, ensuring high-quality data collection and real-world evidence generation.
• Site Performance & Issue Resolution
  Evaluate site performance, identify risks, and implement solutions to ensure studies are delivered on time and to quality standards.
• Cross-Functional Collaboration
  Partner with project teams, medical, data management, and commercial stakeholders to ensure efficient study delivery and reporting.
• Training & Mentorship
  Provide guidance and support to site personnel and junior CRAs, maintaining consistency and best practice, where applicable.
• Stakeholder Engagement
  Build strong relationships with investigators and site staff to drive engagement and successful study execution.

Your Profile

• Advanced degree in Life Sciences, Nursing, Pharmacy, or Medicine
• Significant experience as a Clinical Research Associate, ideally within late phase / Phase IV / real-world studies
• Experience across both investigational product (IP) and medical device trials is highly desirable
• Strong understanding of ICH-GCP, regulatory requirements, and post-marketing study environments
• Proven ability to manage multiple sites and competing priorities
• Expertise in site monitoring, data integrity, and risk-based monitoring approaches
• Proficiency in clinical systems (e.g., CTMS, EDC)
• Willingness to travel across the UK to perform on-site visits
• Full UK driving license
• Excellent communication, stakeholder management, and influencing skills