Senior Clinical Research Associate

Senior Clinical Research Associate

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

What You Will Do:

Key responsibilities include:

• Conduct site qualification, initiation, monitoring, and close-out visits across assigned studies
• Take full ownership of investigator sites, ensuring effective management in line with the Clinical Monitoring Plan (CMP) and study requirements
• Ensure investigator site compliance with study protocols, ICH GCP, SOPs, and applicable regulatory requirements
• Build and maintain strong, long-term relationships with investigators and site personnel, providing ongoing training and support
• Support study start-up activities, including essential document collection, regulatory submissions, and Ethics Committee interactions
• Identify site-level risks and drive corrective and preventive actions to ensure study quality and timelines
• Collaborate with cross-functional teams and support study delivery, including budget/contract discussions and informed consent development ​

Your Profile:

To succeed in this role, you will bring strong clinical research experience, a proactive mindset, and the ability to work independently while maintaining high quality standards.

Required qualifications and experience:

• A degree in life sciences or a related discipline
• Minimum of 5 years’ experience in clinical monitoring and investigator site management within a CRO or pharmaceutical environment
• Strong knowledge of ICH GCP, local, and international regulatory requirements
• Experience across the full trial lifecycle, including start-up, monitoring, and close-out activities
• Willingness and ability to travel up to 60% and hold a valid driver’s license, and be based in Johannesburg
• Experience in diabetes, cardiology, or obesity is advantageous

What ICON can offer you:
Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs.
• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well-being.
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.

Are you a current ICON Employee? Please click here to apply