Senior Clinical Trial Manager and Clinical Trial Manager

Sr CTM & CTM - Colombia, Argentina and/or Chile - Remote

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

Senior Clinical Trial Manager (Senior CTM) & Clinical Trial Manager (CTM)

The Senior Clinical Trial Manager and Clinical Trial Manager profile is responsible for the end-to-end operational oversight of assigned clinical trials, ensuring delivery against agreed timelines, budget, and quality standards. This includes oversight of site management (remote and onsite), clinical team activities, and compliance with regulatory requirements.

Sr CTM and CTM roles leads Clinical Operations execution and serves as the primary point of accountability for trial delivery, working cross-functionally with internal teams and externally with sponsors.

Key Responsibilities:

• Trial Execution & Oversight

  • Plan and manage all clinical operations activities across assigned trials.

  • Ensure delivery in line with scope, timelines, budget, and quality expectations.

  • Oversee site lifecycle activities, including start-up, activation, monitoring, and close-out.

• Team Leadership & Oversight

  • Lead and oversee project specific operational activities of Clinical Research Associates (CRAs) and Site Management Associates (SMAs).

  • Provide direction, training, and study performance oversight for clinical team members.

  • Review monitoring reports, documentation, and study deliverables for quality and compliance.

  • May act as a mentor to study assigned CRAs, SMAs, and/or other department CTMs. (Sr CTM)

• Site & Monitoring Management

  • Develop and implement site management and monitoring plans.

  • Oversee remote and onsite monitoring activities, including visit planning and execution.

  • Ensure timely collection, review, and maintenance of trial documentation in CTMS.

• Stakeholder Management

  • Collaborate with cross-functional teams (Project Management, Data Management, Finance).

  • Build and maintain strong relationships with sponsors and external partners.

  • Provide status updates, metrics, and key study insights to stakeholders.

• Compliance & Governance

  • Ensure adherence to ICH-GCP, regulatory requirements, and internal SOPs.

  • Support audit and inspection readiness.

• Additional Contributions

  • Participate in bid defense activities as required.

  • Contribute to department initiatives, process improvements and operational best practices.

Qualifications & Experience

• Bachelor’s degree in life sciences or related field (or equivalent experience) with at least 1+ year of experience in a CTM or equivalent role (CRO or pharmaceutical environment) (CTM)

• Bachelor’s degree in life sciences or related field (or equivalent experience) with at least 3+ years of experience in a CTM or equivalent role (CRO or pharmaceutical environment) (Sr CTM)

• Experience managing Phase III and/or IV clinical trials across multiple therapeutic areas.

• Knowledge of risk-based monitoring (RBM) principles preferred

• Experience managing North American studies

• Ability to manage multiple studies and priorities in a fast-paced environment

• Strong leadership, organizational, and problem-solving skills

• Effective communication and stakeholder management skills

• Willingness to travel (~15%)

Key Competencies

• Leadership and team management

• Strategic planning and execution

• Risk assessment and mitigation

• Decision-making and problem-solving

• Cross-functional collaboration

• Communication and stakeholder engagement

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What ICON can offer you:
Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs.
• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well-being.
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.

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