JUMP TO CONTENT
Shortlist
search jobs Search

Our Culture Application Process Career Resources Our Mission & Values

Principal Statistician - Europe home based or office based

JR062558

About the role

This vacancy has now expired. Please click here to view live vacancies.
Principal Biostatistician
ICON is a global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries. We specialize in the strategic development, management and analysis of programs that support Clinical Development - from compound selection to Phase I-IV clinical studies.
Position Summary
This position will be accountable for the leadership of the Biostatistics and Programming activities of a program of studies of moderate complexity and/or of high value with high impact for the organization. Also responsible for planning, monitoring, organizing and reviewing activities of biostatisticians and programmers working on the assigned program of studies, ensuring individual studies and the overall program of studies and integrated analyses are delivered on time, on budget to required quality. Accountabilities also include maintenance of consistency across studies. Role could be based at our North Wales office or Home based.
Responsibilities:
  • Accountable for leading Biostatistics and Programming activities for a program of studies of high complexity and/or of high value with high impact.
  • Bio statistical input into the design of the program, Protocol input such as study design, sample size calculations and patient randomization schemes and Statistical aspects of case report form design
  • Review project database structures, edit checks and data management coding conventions
  • Preparation of statistical analysis plans including the definition of derived data, and the design of statistical tables, figures, and data listings for clinical summary reports
  • Statistical analysis, Interpretation of data and reporting of results.
  • Writing of the statistical methods sections of integrated study reports. Reviews draft integrated study reports.
  • Supports responses to regulatory questions on the design of the program, and any labelling claims following submission
  • Participates in presentations at client and investigator meetings.
  • Preparation of biostatistics input to ICON research proposals, and participates in proposal defense meetings and makes presentations at marketing meetings with prospective client.
  • Ongoing coaching and mentorship of team members.

Key Requirements:
  • M.S. degree in statistics, biostatistics, with relevant experience in the pharmaceutical industry or Ph.D. in statistics, biostatistics
  • Experience with oncology is required
  • In-depth knowledge of study designs, and statistical analysis applications in one or more therapeutic areas.
  • Excellent verbal and written communication skills as well as interpersonal and project management skills
  • Excellent knowledge of a wide variety of principles, theories and concepts in statistics and experimental design; must be able to apply them to the development and analysis of clinical trials
  • Excellent knowledge of clinical trials methodology, regulatory requirements, statistics and statistical software packages, including SAS are a must.
  • Experience leading a regulatory submission
  • Must be able to translate clients' needs into statistical practice and educate clients in the use of statistics.
List #1

Day in the life

Izabella's Journey Back to ICON

Teaser label

Our People

Content type

Blogs

Publish date

01/26/2026

Summary

Sometimes the best way to recognise what you have is to experience life without it. For Izabella Grimaldi, a Clinical Research Associate II based in Brazil, that realisation came after seven months wo

Teaser label

Izabella shares what makes our culture, leadership, and opportunities worth coming back for.

Read more
Asian female looking through microscope in lab
Understanding CRA, CTA, and SMA Roles in Clinical Research

Teaser label

Industry

Content type

Blogs

Publish date

01/20/2026

Summary

Understanding the Difference Between CRA, CTA, and SMA Clinical research job titles can be confusing, particularly for those new to the industry. Acronyms such as CRA, CTA and SMA appear frequentl

Teaser label

This guide explains the differences, responsibilities, and how each role supports clinical trial delivery.

Read more
video job interview
Interviewing at ICON

Teaser label

Inside ICON

Content type

Blogs

Publish date

01/05/2026

Summary

Interviewing at ICON: What to Expect Applying for a new role can feel uncertain, particularly when recruitment processes use digital tools or assessments that may be unfamiliar. At ICON, we want ca

Teaser label

Learn what to expect when interviewing at ICON, and how hiring decisions are always made by people.

Read more
View all

Similar jobs at ICON

Senior Clinical Associate

Salary

Location

Mexico, Mexico City

Location

Sao Paulo

Mexico City

Remote Working

Remote

Business Area

ICON Strategic Solutions

Job Categories

Early Phase Services

Job Type

Permanent

Description

We are currently seeking a Senior Clinical Associate to join our diverse and dynamic team. As a Clinical Associate at ICON, you will play a pivotal role in supporting the design, implementation, and m

Reference

JR143266

Expiry date

01/01/0001

Ana Tello

Author

Ana Tello
Ana Tello

Author

Ana Tello
Read more Shortlist Save this role
Read more Shortlist Save this role
Regulatory CMC Strategist

Salary

Location

US, Blue Bell (ICON)

Location

Blue Bell

Remote Working

Remote

Business Area

ICON Strategic Solutions

Job Categories

Drug / Device Regulatory Affairs

Job Type

Permanent

Description

We are currently seeking a Manager, Regulatory Strategy to join our diverse and dynamic team. As a Manager, Regulatory Strategy at ICON, you will play a pivotal role in shaping and implementing strate

Reference

JR143473

Expiry date

01/01/0001

Melissa Benner

Author

Melissa Benner
Melissa Benner

Author

Melissa Benner
Read more Shortlist Save this role
Read more Shortlist Save this role
Clinical Research Lead (Site Engagement)

Salary

Location

Canada, Burlington

Location

Burlington

Remote Working

Remote

Business Area

ICON Strategic Solutions

Job Categories

Clinical Trial Liaison

Job Type

Permanent

Description

What you will be doing Clinical Investigator Management Accountable for the full spectrum of investigator engagement from identification and qualification through enrollment, and support database lock

Reference

JR143390

Expiry date

01/01/0001

Jonathan Holmes

Author

Jonathan Holmes
Jonathan Holmes

Author

Jonathan Holmes
Read more Shortlist Save this role
Read more Shortlist Save this role
Clinical Research Associate - Oncology - Connecticut

Salary

Location

Connecticut

Location

Connecticut

Remote Working

Remote

Business Area

ICON Strategic Solutions

Job Categories

Clinical Monitoring

Job Type

Permanent

Description

What You Will Be Doing:Serve as the primary point of contact between investigational sites and the sponsorConduct all types of site visits, including selection, initiation, routine monitoring, and clo

Reference

JR143255

Expiry date

01/01/0001

Monica Hawkins

Author

Monica Hawkins
Monica Hawkins

Author

Monica Hawkins
Read more Shortlist Save this role
Read more Shortlist Save this role
Clinical Research Coordinator - Statesville, NC

Salary

Location

US, Piedmont, NC

Department

Accellacare Site Network

Location

Piedmont

Statesville

Remote Working

Office Based

Business Area

ICON Full Service & Corporate Support

Job Categories

Clinical Research Site Services

Job Type

Permanent

Description

This role is with Accellacare, part of ICON's clinical research network, where you’ll play a key role in transforming the clinical trial experience for patients and sponsors alike. Our global site net

Reference

JR142157

Expiry date

01/01/0001

Sasha Brown

Author

Sasha Brown
Sasha Brown

Author

Sasha Brown
Read more Shortlist Save this role
Read more Shortlist Save this role
Clinical Research Coordinator

Salary

Location

US, Rocky Mount, NC

Department

Accellacare Site Network

Location

Rocky Mount

Remote Working

Office Based

Business Area

ICON Full Service & Corporate Support

Job Categories

Clinical Research Site Services

Job Type

Permanent

Description

This role is with Accellacare, part of ICON's clinical research network, where you’ll play a key role in transforming the clinical trial experience for patients and sponsors alike. Our global site net

Reference

JR142165

Expiry date

01/01/0001

Sasha Brown

Author

Sasha Brown
Sasha Brown

Author

Sasha Brown
Read more Shortlist Save this role
Read more Shortlist Save this role
View Jobs

Browse popular job categories below or search all jobs above