Principal Clinical Data Science Lead

As a Principal Clinical Data Science Lead you will be joining the world’s largest & most comprehensive clinical research organisation, powered by healthcare intelligence.

In this role you will be responsible for overseeing all aspects of clinical data management for assigned trials, ensuring data integrity, regulatory compliance, and timely deliverables. The role includes cross-teams collaboration, internal teams, and vendors. The Principal Clinical Data Science Lead ensures the accuracy and completeness of clinical data for regulatory submissions and supports process improvements.

What you will be doing:

• Lead and align data management expectations with CROs, clinical study teams, and stakeholders.
• Oversee outsourced data management deliverables per scope and trial oversight plans.
• Ensure timely creation and quality of essential documents (e.g., DMPs, UAT plans, archival packages).
• Monitor trial progress against project plans, KPIs, and budgets; adjust as needed.
• Develop and manage Data Release Plans in accordance with blinding rules and stakeholder input.
• Perform quality control checks for data completeness and accuracy.
• Contribute to departmental process improvements and support audits and inspections.

You are:

• Bachelor’s or Master’s Degree in Life Sciences, Pharmacy, Mathematics, or related field, or equivalent experience.
• 10 years of work experience within the Data Management field, with at least 7 years as a lead for the principal level.
• Proven experience in Clinical Data Management, including managing CROs and vendors.
• Strong knowledge of GCP, CDISC (CDASH, SDTM, ADaM), FDA, and ICH guidelines.
• Proficient with clinical study tools (eCRF systems, study progress tracking, metadata repositories).
• Previous work experience to support phase I studies.
• Excellent attention to detail and analytical problem-solving skills.
• Strong interpersonal and communication skills; effective in team and independent settings.
• Experience in autoimmune and/or orphan disease trials is a plus.

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs
• Competitive retirement planning offerings to maximise savings and plan with confidence for the years ahead
• Global Employee Assistance Programme, TELUS Health, offering 24-hour access to a global network of over 80,000 independent specialised professionals who are there to support you and your family’s well-being
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidised travel passes, health assessments, among others

Visit our careers website to read more about the benefits of working at ICON: https://careers.iconplc.com/benefits

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know through the form below.

https://careers.iconplc.com/reasonable-accommodations

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.