Principal Scientist
About the role
This vacancy has now expired. Please click here to view live vacancies.
*Recognize, exemplify and adhere to ICON's values which centers around our commitment to People, Clients and Performance.
* As a member of staff, the employee I expected to embrace and contribute to our culture of process improvement with a focus on streamlining our processes adding value to our business and meeting client needs.
* Travel (approximately 1%) domestic and/or international.
* *Perform Bioanalytical method development and method validation for the quantification of NCE, NBE and Biomarkers in tissues and biological fluids.
* * Work with clients to bring externally established assays and technologies in-house and/or transfer in-house assays externally as required.
* Prepare Bioanalytical method documents.
* *May manage analytical studies and act as scientific consultant to clients, and internal scientific consultant within Icon.
* *Work with laboratory management to ensure that appropriate resources are available to complete the study to timeline. May obtain all client specific documents required for the analysis, ie study protocol, randomization lists, COA, demographic etc
* *Prepare analysis plans suitable to the clients needs and obtain client approval of these.
* *Supervise analytical teams to ensure that study plans and validation plans, as appropriate are complied with.
* *Work with clients to ensure studies are conducted in a manner compliant with the clients stated needs as defined by contract, and that the project delivery, reporting specifics, timelines agreed to are met. Inform DM and QC/QA of deadlines.
* *Where appropriate, prepare invoice requests at agreed milestones ensuring that both ICON finance and the client has all necessary information to allow the invoice to be approved for payment.
* *Maintain records of work conducted in a timely and consistent manner, sufficient to allow real-time tracking of the deliverables, including tracking of revenue and resources associated with assigned studies. Inform stakeholder of changes to scope or timelines.
* Identify changes to scope of work and notify contracts of need for change order.
* *Review all data in accordance with direction documents and ensure results are documented accurately, completely and compliant with GLP/GCP regulations and SOPs .
* *Assist Project Leaders and lab staff in proactively identifying possible/potential implications of unusual results. Assist as required in an investigation and report findings.
* *Perform assay for the routine batch analysis of NCE, NBE and Biomarkers in tissues and biological fluids involving simple and complex analytical techniques. Perform laboratory work to GLP/GCP standard.
* *Document all work and results accurately, completely and compliant with GXP regulations and SOP's.
* *Generate high quality analytical results. Ensure smooth transfer of data to PI's and participate in evaluation and interpretation of data.
* *Lead investigations of instrumental and procedural problems.
* *Evaluate new equipment or technologies and make recommendations to management on utility for the laboratory and business.
* Approve release of method development and non-GXP data
* *Prepare reports (or oversee as appropriate) of the work conducted, address all QA findings and provide QA draft report in line with the terms and conditions stated in the signed contract.
* Ensure that all documentation is appropriately archived on completion of the study.
* *Check and verify laboratory notebooks and other analytical data as required.
* *Author SOPs as needed. Maintain awareness of and adherence to all current SOPs.
* *Work in compliance with GXP.
* All other duties as needed.
Impactful work. Meaningful careers. Quality rewards.
At ICON, our employees are our greatest strength. That’s why we are committed to empowering you to live your best life, both inside and outside of work. Whether your ambition is lead a global team, become a deep scientific or technical expert, work in-house with our customers or gain experience in a variety of different ICON functions, we will support you in realising your full potential. See all locations Learn more about Our Culture at ICON
Day in the life
.png)
Teaser label
IndustryContent type
BlogsPublish date
05/29/2025
Summary
Blood Cancer Day Blood Cancer Day is a powerful reminder of the millions of individuals and families whose lives are affected by hematological malignancies every year. These diseases are complex,
.png)
Teaser label
IndustryContent type
BlogsPublish date
05/22/2025
Summary
World Schizophrenia Awareness Day 2025 Every year on 24 May, World Schizophrenia Awareness Day offers a vital opportunity to raise awareness, dismantle stigma, and celebrate the strength of individ
.png)
Teaser label
Inside ICONContent type
BlogsPublish date
05/08/2025
Summary
Standing Strong on Ovarian Cancer Day: ICON's Commitment to Advancing Care Ovarian cancer remains one of the most challenging gynaecologic malignancies, both in terms of detection and treatmen
Similar jobs at ICON
Salary
Location
Czech Republic, Prague
Department
Clinical Monitoring
Location
Prague
Remote Working
Office Based
Business Area
ICON Full Service & Corporate Support
Job Categories
Intern
Job Type
Intern
Description
We are currently seeking an Intern to join our diverse and dynamic team. As an Intern at ICON, you will have the opportunity to gain hands-on experience in a professional environment, supporting vario
Reference
JR131143
Expiry date
01/01/0001
Author
Lauren PritchettAuthor
Lauren PritchettSalary
Location
US, Blue Bell (ICON)
Department
Full Service - Development & Commercialisation Solutions
Full Service - Global Business Services
Location
New York
Blue Bell
Remote Working
Office Based
Business Area
ICON Full Service & Corporate Support
Job Categories
Project/ Program Management
Job Type
Permanent
Description
Program Manager, Labs – Blue Bell PA, Farmingdale NY- Hybrid. Assist the team of PMs in issue resolution / escalation during the lifetime of all trials • Understand your Project Managers’ performa
Reference
JR130137
Expiry date
01/01/0001
Author
Frank LampartAuthor
Frank LampartSalary
Location
United States
Department
Regulatory, Drug Safety/ Quality Assurance & Other roles
Location
United States
Remote Working
Remote
Business Area
ICON Strategic Solutions
Job Categories
Other
Job Type
Permanent
Description
As a Surgical Science Liaison (Neurosurgery) – Part-time/Contract, you will join the world’s largest and most comprehensive clinical research organization, driven by healthcare intelligence.
Reference
2025-119361
Expiry date
01/01/0001
Salary
Location
US, Lenexa KCI (PRA)
Department
Full Service - Early Clinical and Bioanalytical Solutions
Location
Lenexa
Remote Working
Office Based
Business Area
ICON Full Service & Corporate Support
Job Categories
Laboratory Support
Job Type
Temporary Employee
Description
We are currently seeking a Lab Analyst II to join our diverse and dynamic team. As a Lab Analyst II at ICON, you will be responsible for performing intermediate-level laboratory tests and analyses to
Reference
JR127410
Expiry date
01/01/0001
Author
Kahla CuretonAuthor
Kahla CuretonSalary
Location
Mexico, Mexico City
Department
Full Service - Corporate Support
Location
Mexico City
Remote Working
Office Based
Business Area
ICON Full Service & Corporate Support
Job Categories
HR Advisor
Job Type
Permanent
Description
Hybrid Role: 3 days in the office / 2 days remote (home office)Location: Insurgentes Sur, Mexico CityWe are currently seeking an HR Advisor to join our diverse and dynamic team supporting our Canadian
Reference
JR131083
Expiry date
01/01/0001
Author
Daniela GuerreroAuthor
Daniela GuerreroSalary
Location
US, Lenexa KCI (PRA)
Department
Full Service - Early Clinical and Bioanalytical Solutions
Location
Lenexa
Remote Working
Office Based
Business Area
ICON Full Service & Corporate Support
Job Categories
Laboratory
Job Type
Permanent
Description
We are currently seeking a Manager, PK Laboratory to join our diverse and dynamic team. As a Manager, PK Laboratory at ICON, you will be responsible for overseeing all pharmacokinetics (PK) laboratory
Reference
JR128689
Expiry date
01/01/0001
Author
Kahla CuretonAuthor
Kahla Cureton