Principal Clinical Data Science Lead (Client dedicated)

ICON plc is a world-leading healthcare intelligence and clinical research organisation. From molecule to medicine, we advance clinical research providing outsourced services to pharmaceutical, biotechnology, medical device and government and public health organisations. With our patients at the centre of all that we do, we help to accelerate the development of drugs and devices that save lives and improve quality of life.

Join our Biometrics team and take the lead in delivering high-quality clinical data for pivotal trials across multiple phases and therapeutic areas. You’ll be a strategic partner, managing complex data management programs and guiding cross-functional teams to success. This is your opportunity to influence global submissions and ensure excellence in clinical data operations.

What you will be doing:

• Lead end-to-end Data Management activities for global/regional clinical trials (Phase I–IV), ensuring time, cost, and quality targets are met.

• Serve as the primary Data Management representative within Global Trial Teams, providing strategic and operational leadership.

• Oversee CROs and vendors, ensuring compliance with scope, timelines, quality standards, and regulatory requirements.

• Develop and execute data collection strategies in alignment with company standards (CDISC SDTM, ICH-GCP).

• Ensure database quality, submission readiness, and timely delivery of data packages to regulatory authorities.

• Lead the development and review of Data Management Plans, SOPs, and operational documents.

• Manage trial budgets for Data Management deliverables, including forecasting and cost control.

• Drive continuous process improvement and mentor team members across projects.

You Possess:

• Advanced degree in Life Sciences, Mathematics, Computer Sciences, or equivalent industry experience.

• Minimum 10 years’ proven experience in Clinical Data Management within pharma/biotech, including substantial project management leadership.

• Expert knowledge of ICH-GCP, major health authority regulations (FDA, EMA, PMDA, etc.), and CDISC standards.

• Proficiency with industry EDC systems (e.g., Medidata Rave, InForm) and related platforms (ePRO, eHR).

• Demonstrated success in leading cross-functional, global teams in a matrix environment.

• Strong vendor management experience, including oversight of CROs for large-scale trials.

• Exceptional analytical, problem-solving, and decision-making skills with a focus on quality and compliance.

• Excellent communication and stakeholder management skills, with the ability to influence at all organizational levels.

• Preferred work experience in oncology and/or neurology

Benefits of Working in ICON:

Our success depends on the knowledge, capabilities and quality of our people. That’s why we are committed to developing our employees in a continuous learning culture – one where we challenge you with engaging work and where every experience adds to your professional development.

At ICON, our focus is to provide you with a comprehensive and competitive total reward package that comprises, not only an excellent level of base pay, but also a wide range of variable pay and recognition programs.  In addition, our best in class employee benefits, supportive policies and wellbeing initiatives are tailored to support you and your family at all stages of your career - both now, and into the future.

ICON, including subsidiaries, is an equal opportunity and inclusive employer and is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know.